Medical Grand Rounds

Spring 2008
12:00 Noon
Hermes A. Kontos
Medical Sciences Building Auditorium

January | February | March | April | May

JANUARY

3-Jan	New Treatment Paradigms for Gleevec-Resistant CML: Bench to Bedside Steven Grant, MD Shirley Carter and Sture Gordon Olsson Professor of Oncology Associate Director of Translational Research, Massey Cancer Center Department Of Internal Medicine Division of Hematology/Oncology & Palliative Care Virginia Commonwealth University Medical Center Learning Objectives: Following this Grand Rounds presentation, participants will be able to: To understand the molecular pathogenesis of chronic myelogenous leukemia To understand mechanisms by which CML patients become resistant to imatinib mesylate To learn about new ways novel kinase inhibitors are being used to circumvent imatinib mesylate resistance in patients with CML
10-Jan	Diuretic Therapy: Principles and Practice Domenic A. Sica, MD Professor and Chair Section of Clinical Pharmacology and Hypertension Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives: Following this Grand Rounds presentation, participants will be able to: To understand the mechanism of action of commonly available diuretics To appreciate the role of diuretic absorption in their action To be aware of the side-effects commonly seen with diuretics To understand intraclass differences amongst loop and potassium-sparing diuretics
17-Jan	*Residual Cardiovascular Risk in Diabetic Patients: Can Glucose Lowering reduce CV events?* Richard W. Nesto, MD Associate Professor of Medicine Chair, Department of Cardiovascular Medicine Lahey Clinic Medical Center Harvard University School of Medicine Learning Objectives: Following this Grand Rounds presentation, participants will be able to: To learn about the relation between glucometrics and CV risk To understand the mechanisms responsible for CV risk despite adequate CV risk factor control To evaluate the potential of antidiabetic medications to reduce CV risk
24-Jan	Chronic Gastroparesis: Not Quite Paralyzed Arthi Sanjeevi, MD Assistant Professor, Division of Gastroenterology, Section of Hepatology Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Understand Gastric Motor Function in health Itiopathogenesis of Gastric Motor Dysfunction aka Gastroparesis Diagnostic options—When and what to test/and not to test Management—Tricks of the trade and newer options
31-Jan	FELLOWS' RESEARCH DAY *Differences in Breast Cancer Diagnosis and Treatment: Experiences of Insured and Uninsured Patients in a Safety Net Setting* Nicholas Farrell, MD Fellow, Hematology/Oncology Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives: Describe the safety net system Discuss the results of this study comparing treatment for insured and uninsured breast cancer patients Cardiac Arrest in the ED: A Report of the National Registry of CardioPulmonary Resuscitation Robert Kayser, MD, MBA Fellow, Interventional Cardiology Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives: Understand the nature of the ED cardiac arrest patient population Understand outcomes associated with cardiac arrest in various units of a hospital Predictors of Chronic Kidney Disease Progression in Long-Term Survivors of Liver Transplantation Ramesh Kotihal, MD, MS Fellow, Nephrology Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives: Identify Chronic Kidney Disease as an increasingly recognized complication after Liver Transplantation Determine which patients are at an increased risk of Chronic Kidney Disease progression after Liver Transplantation

FEBRUARY

7-Feb	Ocular Manifestations of Systemic Disease William Benson, MD Professor and Chair, Department of Ophthalmology Virginia Commonwealth University Medical Center Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Understand and describe the various categories of systemic disease states that can affect the eyes and vision (i.e., genetic, endocrine, metabolic, infectious, immunologic, neoplastic, and traumatic). Identify the association between systemic diseases that affect patients and their potential for ocular manifestations.
14-Feb	*Clinicopathologic Conference* Discussant: Jeff Kushinka, MD Assistant Professor, Division of General Medicine Department of Internal Medicine Virginia Commonwealth University School of Medicine CPC Protocol prepared by Elizabeth Naylor, MD (pdf) Learning Objectives: Following this Grand Rounds presentation, participants will be able to: To recognize etiologies and diagnosis from the clinicopathologic case presented To observe an experienced clinician's diagnostic reasoning process
21-Feb	Why Study the Rational Clinical Examination? David L. Simel, MD, MHSc Associate Professor Division of General Internal Medicine Department of Medicine Duke University Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Outline a role for the Rational Clinical Examination Series in clinical care and teaching. Using Influenza as an example, describe how historical items can be used quantitatively to assess the probability of influenza. Explain how Likelihood ratios are the parameter for assessing the diagnostic impact of clinical findings Pose a series of questions regarding the responsibility of a Student, Attending physician, and Institution in both learning and using the results of the clinical examination Briefly describe the USMLE Clinical Skills test and how evidence is used to guide its formulation
28-Feb	The Sullivan Alliance: A National Strategy to Diversify the Health Professions Louis Sullivan, MD Former U.S. Secretary of Health and Human Services, Founding dean, director, and president emeritus of the Morehouse School of Medicine Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Describe the disparities in health status between whites and the nation's minority populations Discuss the low representation of minorities in the health professions Explain how the low representation of minorities in the health professions contributes to health disparities Identify national and state strategies to increase racial and ethnic diversity among the nation's health professionals

MARCH

6-Mar	What Can Diets Do for Obesity and Related Diseases? William S. Yancy, Jr., MD, MHSc Assistant Professor Department of Medicine Division of General Internal Medicine Duke University School of Medicine Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Explain the history of low-carbohydrate diet use and discuss recent epidemiological studies that conflict with the diet-heart hypothesis Describe the weight loss and metabolic effects of low-carbohydrate diets seen in clinical trials Identify the effects of the low-carbohydrate diet on diabetes management seen in clinical trials
13-Mar	Clostridium Difficile: Resurgence of an Old Pathogen Gonzalo Bearman, MD, MPH Assistant Professor of Internal Medicine Associate Hospital Epidemiologist Division of Quality Health Care Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives: Following this Grand Rounds presentation, the learner will be able to: Explain the importance of C-difficile as a nosocomial pathogen Describe the emergence of a hypertoxic producing variant of C-difficile Identify the treatment options for C-difficile List infection control principles for the management of C-difficile
20-Mar	Prevention of Healthcare-Associated Infections: Science, Practices and Policies Denise Cardo, MD Director, Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Describe the scope of healthcare-associated infections in the United Sates Discuss local/regional initiatives to prevent healthcare-associated infections Provide an overview of current state and federal legislation/regulation regarding healthcare-associated infections
26-Mar	SPECAIL WEDNESDAY GRAND ROUNDS Evaluating the Safety and Effectiveness of Medical Interventions: The Scientific Basis of Drug Regulation John H. Powers, MD Assistant Professor George Washington University School of Medicine Former Lead Medical Officer Antimicrobial Drug Development and Resistance Initiatives Office of Drug Evaluation IV Center for Drug Evaluation and Research U.S. Food and Drug Administration Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Discuss the history of drug regulation in the United States Identify the standards by which drugs are approved Explain the difference between evaluating safety and effectiveness

APRIL

3-Apr	ANNUAL CHARLES THOMAS LECTURE Organized by the Division of Rheumatology, Allergy & Immunology Management Issues in Women with SLE Rosalind Ramsey-Goldman, MD, DrPH Solovy Arthritis Research Society Professor Research Professor of Medicine Northwestern University Feinberg School of Medicine Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Describe childbearing issues relevant for the young woman with lupus Counsel a lupus patient to plan for a future pregnancy Discuss cardiovascular complications in women lupus Counsel a lupus patient on what can be done to prevent cardiovascular complications
10-Apr	*Housestaff Research Presentations* Christopher Gelwix, MD, MSc, Categorical, 2010 Variant Angina Refractory To Treatment – A Rare Occurrence J. Daniel Markley, DO, Categorical, 2010 Is MRSA hiding in the Gym? Jared Shipley, MD, Categorical, 2008 Hospital-Acquired Endocarditis Amit Varma, MD, Physician-Scientist, 2013 Does Etiology of Anemia Predict Outcome in Patients Undergoing Coronary Stenting? Raquel Villavicencio MD, Women's Health, 2009 Pulmonary Embolism, Ventricular Thrombus, and Myocardial Infarction: The Triple Threat of Peripartum Cardiomyopathy Abstracts (pdf) Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Gain an appreciation for the breadth and depth of scholarly activities for resident trainees Gain exposure to several unique case presentations for the inpatient setting at VCUHS Recognize the complexity of patient pathology in the educational VCUHS setting
17-Apr	The Great Debate: Obesity vs. Tobacco— Which is the Greater Health Hazard? Wally R. Smith, MD Professor and Chair Division of Quality Health Care Department of Internal Medicine Virginia Commonwealth University Medical Center VS. Arun J. Sanyal, MD Professor and Chair Division of Gastroenterology, Hepatology and Nutrition Department of Internal Medicine Virginia Commonwealth University Medical Center Learning Objectives Obesity: Following this Grand Rounds presentation, participants will be able to: Evaluate the public health impact of disease Explain the consequences of obesity on the health of an afflicted individual Identify causes of morbidity and mortality in the USA and describe the attributable risks from obesity Learning Objectives Tobacco : Following this Grand Rounds presentation, participants will be able to: Describe the mortality impact of smoking in the United States Describe the various diseases associated with smoking in the United States Compare the relative attributable mortality of obesity and physical inactivity versus tobacco in the United States, and its change over time Discuss various helps and methods physicians can use for smoking cessation in their patient
24-Apr	The Adult with Cystic Fibrosis Patrick Flume, MD Professor of Medicine & Pediatrics Pulmonary and Critical Care Division Medical University of South Carolina Learning Objectives: Following this Grand Rounds presentation, participants will be able to: Describe the pathophysiology of cystic fibrosis List the known complications of cystic fibrosis Discuss the current therapies used to treat patients with cystic fibrosis Discuss the approach to diagnosis and treatment of an acute exacerbation of CF lung disease

MAY

1-May	*Asthma: Do We Really Know All We Should to Treat Our Patients?* Stephen I. Wasserman, MD Professor of Medicine Section of Allergy and Immunology Department of Medicine University of California, San Diego School of Medicine Learning Objectives: Following the Grand Rounds presentation, participants will be able to: Discuss current controversies in asthma treatment Suggest alternative treatments for patients Differentiate between population responses and individual responses to medications
8-May	ANNUAL MARKHAM AWARD LECTURE Organized by the Division General Medicine Outcomes and Evidence: Making Tomorrow's Vision Today's Reality through Patient-Centered Care Carolyn Clancy, MD Director, Agency for Healthcare Research and Quality U.S. Department of Health and Human Services Learning Objectives: Following the Grand Rounds presentation, participants will be able to: Describe key public- and private-sector issues and activities that are helping to promote patient engagement in the transformation of the U.S. health care system Outline the roles that the U.S. Department of Health and Human Services and Agency for Healthcare Research and Quality play in areas including patient-centered care, health IT and value-driven health care Identify how the relationships between these efforts and strategies will transform 21st century health care into an information-rich, patient-focused enterprise
15-May	*Clinicopathologic Conference* Discussant: TBA Department of Internal Medicine Virginia Commonwealth University School of Medicine Radiologist: TBA Department of Radiology Virginia Commonwealth University School of Medicine Pathologist: TBA Department of Pathology Virginia Commonwealth University School of Medicine Learning Objectives: Following this Grand Rounds presentation, participants will be able to: To recognize etiologies and diagnosis from the clinicopathologic case presented To observe an experienced clinician's diagnostic reasoning process Note Location Change: GBJ Auditorium
22-May	ANNUAL WILLIAM BLACKARD LECTURE Organized by the Division of Endocrinology & Metabolism Shalender Bhasin, MD Professor and Chief Section of Endocrinology, Diabetes and Nutrition Department of Internal Medicine Boston University Medical Center Learning Objectives: TBA
29-May	DEPARTMENT OF INTERNAL MEDICINE GRADUATION & RECOGNITION CEREMONY Stephanie A. Call, MD, MSPH Associate Professor and Residency Program Director Department of Internal Medicine Virginia Commonwealth University Medical Center Please join us as we recognize DOIM resident, fellow and faculty accomplishments. Reception and research poster presentation immediately following ceremony in MSB rooms 104 & 105.

Grand Rounds Calendar Subject to Change

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Virginia Commonwealth University \| VCU Health System School of Medicine \| Department of Internal Medicine Updated: 05/02/2008

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